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- PMID: 20434500
- UKPMCID: 20434500
- DOI: 10.1016/j.febslet.2010.04.058
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p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss.
Brosh, Ran; Sarig, Rachel; Natan, Elad Bar; Molchadsky, Alina; Madar, Shalom; Bornstein, Chamutal; Buganim, Yosef; Shapira, Tirosh; Goldfinger, Naomi; Paus, Ralf; Rotter, Varda
FEBS letters. 2010;584(11):2473-7.
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Full-text held externally
- PMID: 20434500
- UKPMCID: 20434500
- DOI: 10.1016/j.febslet.2010.04.058
Abstract
The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.