Related resources
Full-text held externally
- PMID: 16815076
- UKPMCID: 16815076
- DOI: 10.1016/j.cytogfr.2006.05.001
Search for item elsewhere
University researcher(s)
Academic department(s)
IL-15/IL-15 receptor biology: a guided tour through an expanding universe.
Budagian, Vadim; Bulanova, Elena; Paus, Ralf; Bulfone-Paus, Silvia
Cytokine & growth factor reviews. 2006;17(4):259-80.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 16815076
- UKPMCID: 16815076
- DOI: 10.1016/j.cytogfr.2006.05.001
Abstract
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.