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Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance.

Peters, Eva M J; Ericson, Marna E; Hosoi, Junichi; Seiffert, Kristina; Hordinsky, Maria K; Ansel, John C; Paus, Ralf; Scholzen, Thomas E

The Journal of investigative dermatology. 2006;126(9):1937-47.

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Abstract

The skin as a barrier and immune organ is exposed to omnipresent environmental challenges such as irradiation or chemical and biologic hazards. Neuropeptides released from cutaneous nerves or skin and immune cells in response to noxious stimuli are mandatory for a fine-tuned regulation of cutaneous immune responses and tissue maintenance and repair. They initialize host immune responses, but are equally important for counter regulation of proinflammatory events. Interaction of the nervous and immune systems occurs both locally - at the level of neurogenic inflammation and immunocyte activation - and centrally - by controlling inflammatory pathways such as mononuclear activation or lymphocyte cytokine secretion. Consequently, a deregulated neurogenic immune control results in disease manifestation and frequently accompanies chronic development of cutaneous disorders. The current understanding, therapeutic options, and open questions of the role that neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide, neuropeptide Y, or others play in these events are discussed. Progress in this field will likely result in novel therapies for the management of diseases characterized by deregulated inflammation, tissue remodeling, angiogenesis, and neoplasm.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
126
Issue:
9
Pagination:
1937-47
Digital Object Identifier:
10.1038/sj.jid.5700429
Pubmed Identifier:
16912691
Pii Identifier:
5700429
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:107481
Created by:
Paus, Ralf
Created:
17th January, 2011, 16:33:18
Last modified by:
Paus, Ralf
Last modified:
17th January, 2011, 16:50:20

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