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The role of human papillomavirus vaccines in cervical neoplasia.

Stern, P L; Faulkner, R; Veranes, E C; Davidson, E J

Best practice & research. Clinical obstetrics & gynaecology. 2001;15(5):783-99.

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Abstract

Cervical cancer is the second most common cause of cancer-related death in women, in some developing countries accounting for the highest cancer mortality. The evidence for the association of high-risk human papillomavirus types with the aetiology of cervical neoplasia is firmly established, human papillomavirus being detected in virtually all cervical cancers. The risk of progression of precursor cervical intra-epithelial neoplasia lesions is associated with persistence of human papillomavirus infection. One strategy for the management of cervical neoplasia worldwide could be the development of prophylactic and/or therapeutic human papillomavirus vaccines. This chapter will discuss the natural history of human papillomavirus infection, viral immunity and the clinical course of resultant disease as the background to the effective design and use of human papillomavirus vaccines for protection or therapy. The progress of ongoing phase I and II clinical trials for several different vaccine preparations and the challenges for establishing their future use will be discussed.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
15
Issue:
5
Pagination:
783-99
Digital Object Identifier:
10.1053/beog.2001.0220
Pubmed Identifier:
11563873
Pii Identifier:
S1521693401902202
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:118683
Created by:
Crosbie, Emma
Created:
13th February, 2011, 14:19:24
Last modified by:
Crosbie, Emma
Last modified:
19th February, 2013, 19:29:27

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