Related resources
Full-text held externally
- DOI: 10.1111/j.1365-2133.2011.10237.x
- PMID: 21375519
- UKPMCID: 21375519
Search for item elsewhere
University researcher(s)
Academic department(s)
A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.
Warren, R B; Smith, R L; Flynn, E; Bowes, J; UKRAG_Consortium; Eyre, S; Worthington, J; Barton, A; Griffiths, C E M
The British journal of dermatology. 2011;164(3):660-4.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1111/j.1365-2133.2011.10237.x
- PMID: 21375519
- UKPMCID: 21375519
Abstract
Summary Background  Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. Objectives  The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. Methods  Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform. Results  We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4) ) region. Conclusions  The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases.