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- PMID: 21375519
- UKPMCID: 21375519
- DOI: 10.1111/j.1365-2133.2011.10237.x
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A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.
Warren, R B; Smith, R L; Flynn, E; Bowes, J; ; Eyre, S; Worthington, J; Barton, A; Griffiths, C E M
The British journal of dermatology. 2011;164(3):660-4.
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Full-text held externally
- PMID: 21375519
- UKPMCID: 21375519
- DOI: 10.1111/j.1365-2133.2011.10237.x
Abstract
BACKGROUND: Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression. OBJECTIVES: The purpose of this investigation was to study 21 genetic variants in 14 genes that are confirmed autoimmune loci in a cohort of patients with early-onset psoriasis. METHODS: Patients with early-onset psoriasis (n = 750) and controls (n = 3531) were genotyped using the Sequenom(®) MassArray™ iPLEX Gold platform. RESULTS: We found strong evidence of association with two variants in the IL2/IL21 (rs6822844, genotypic P = 3·3 × 10(-4) ; rs2069778, genotypic P = 7·86 × 10(-4)) region. CONCLUSIONS: The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases.