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EuroPhenome: a repository for high-throughput mouse phenotyping data.

Morgan, Hugh; Beck, Tim; Blake, Andrew; Gates, Hilary; Adams, Niels; Debouzy, Guillaume; Leblanc, Sophie; Lengger, Christoph; Maier, Holger; Melvin, David; Meziane, Hamid; Richardson, Dave; Wells, Sara; White, Jacqui; Wood, Joe; ; de Angelis, Martin Hrabé; Brown, Steve D M; Hancock, John M; Mallon, Ann-Marie

Nucleic acids research. 2010;38(Database issue):D577-85.

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Abstract

The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.

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Place of publication:
England
Volume:
38
Issue:
Database issue
Pagination:
D577-85
Digital Object Identifier:
10.1093/nar/gkp1007
Pubmed Identifier:
19933761
Pii Identifier:
gkp1007
Access state:
Active

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Manchester eScholar ID:
uk-ac-man-scw:124534
Created by:
Muller, Werner
Created:
17th June, 2011, 08:57:23
Last modified by:
Muller, Werner
Last modified:
17th June, 2011, 08:57:23

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