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Age-dependent remodelling of ionotropic signalling in cortical astroglia

Lalo, U; Palygin, O; North, R A; Verkhratsky, A; Pankratov, Y

Aging Cell. 2011;10(3):392-402.

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Abstract

Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial. Stimulation of neuronal afferents in mice neocortex triggers complex glial synaptic currents (GSCs) mediated by NMDA, P2X and AMPA receptors and glutamate transporters. In addition, astrocytes demonstrate spontaneous 'miniature' GSCs resulting from quantal release of neurotransmitters. Here, we demonstrate that maturation and aging of the brain of mice (from 1 to 21 months) affect the density of ionotropic receptors in astrocytes and their role in GSCs generation. The AMPA-receptor-mediated component is the largest in young animals and progressively declines with age. The P2X and NMDA components of GSC are smallest in young, maximal in adult (3 and 6 months old) and once more decrease in old mice, probably reflecting the remodelling of neuronal-glial circuitry. Our results demonstrate that fast synaptic transmission between neurones and astrocytes in neocortex that may be involved in information processing in neuronal-glial networks undergoes remodelling during brain maturation and aging.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Language:
eng
Journal title:
ISSN:
Publisher:
Volume:
10
Issue:
3
Start page:
392
End page:
402
Total:
11
Pagination:
392-402
Digital Object Identifier:
10.1111/j.1474-9726.2011.00682.x
ISI Accession Number:
21272193
Related website(s):
  • Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21272193
General notes:
  • Lalo, Ulyana Palygin, Oleg North, Richard Alan Verkhratsky, Alexei Pankratov, Yuriy BB ââ€ž F021445/Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't England Aging cell Aging Cell. 2011 Jun;10(3):392-402. doi: 10.1111/j.1474-9726.2011.00682.x. Epub 2011 Mar 22.
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:127249
Created by:
Verkhratsky, Alexej
Created:
15th July, 2011, 02:59:36
Last modified by:
Verkhratsky, Alexej
Last modified:
26th October, 2015, 17:02:25

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