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Verification of predicted robustness and accuracy of multivariate analysis
Markiewicz, P J; Matthews, J C; Declerck, J; Herholz, K
Neuroimage. 2011;56(3):1382-5.
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Abstract
The assessment of accuracy and robustness of multivariate analysis of FDG-PET brain images as presented in [Markiewicz, P.J., Matthews, J.C., Declerck, J., Herholz, K., 2009. Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease. Neuroimage 46, 472-485.] using a homogeneous sample (from one centre) of small size is here verified using a heterogeneous sample (from multiple centres) of much larger size. Originally the analysis, which included principal component analysis (PCA) and Fisher discriminant analysis (FDA), was established using a sample of 42 subjects (19 Normal Controls (NCs) and 23 Alzheimer's disease (AD) patients) and here the analysis is verified using an independent sample of 166 subjects (86 NCs and 80 ADs) obtained from the ADNI database. It is shown that bootstrap resampling combined with the metric of the largest principal angle between PCA subspaces as well as the deliberate clinical misdiagnosis simulation can predict robustness of the multivariate analysis when used with new datasets. Cross-validation (CV) and the .632 bootstrap overestimated the predictive accuracy encouraging less robust solutions. Also, it is shown that the type of PET scanner and image reconstruction method has an impact on such analysis and affects the accuracy of the verification sample.
Keyword(s)
*Multivariate Analysis; Aged; Alzheimer Disease/radionuclide imaging; Databases, Factual; Discriminant Analysis; Female; Fluorodeoxyglucose F18/diagnostic use; Humans; Image Processing, Computer-Assisted/*methods; Male; Positron-Emission Tomography/*methods; Principal Component Analysis; Radiopharmaceuticals/diagnostic use; Reproducibility of Results
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- Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21338696
- Markiewicz, P J Matthews, J C Declerck, J Herholz, K Alzheimer's Disease Neuroimaging Initiative (ADNI) K01 AG030514/AG/NIA NIH HHS/United States P30 AG010129/AG/NIA NIH HHS/United States U01 AG024904/AG/NIA NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States NeuroImage Neuroimage. 2011 Jun 1;56(3):1382-5. Epub 2011 Feb 19.