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- DOI: 10.1530/EJE-11-0353
- PMID: 21903895
- UKPMCID: 21903895
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Influence of bone remodeling rate on quantitative ultrasound (QUS) parameters at the calcaneus and DXA BMDa of the hip and spine in middle aged and elderly European men: The European Male Ageing Study (EMAS)
Boonen, Steven; Pye, Stephen R; O'Neill, Terence W; Szulc, Pawel; Gielen, Evelien; Borghs, Herman; Verschueren, Sabine; Claessens, Frank; Adams, Judith E; Ward, Kate A; Bartfai, Gyorgy; Casanueva, Felipe F; Finn, Joseph D; Forti, Gianni; Giwercman, Aleksander; Han, Thang Sieu; Huhtaniemi, Ilpo; Kula, Krzysztof; Labrie, Fernand; Lean, Michael; Pendleton, Neil; Punab, Margus; Silman, Alan J; Tajar, Abdelouahid; Wu, Fredrick; Vanderschueren, Dirk
European journal of endocrinology / European Federation of Endocrine Societies. 2011;165(6):977-986.
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Full-text held externally
- DOI: 10.1530/EJE-11-0353
- PMID: 21903895
- UKPMCID: 21903895
Abstract
Objective: To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men.Design: Cross-sectional population based survey.Methods: Men aged 40-79 years were recruited from population registers in 8 European centres. Subjects completed a postal questionnaire which included questions concerning lifestyle and were invited to attend for quantitative ultrasound (QUS) of the calcaneus and a fasting blood sample from which the bone markers serum N-terminal propeptide of type 1 procollagen (P1NP) and crosslinks (β-cTX), total testosterone (T), total oestradiol (E(2)), sex hormone-binding globulin (SHBG) and insulin-like growth factor (IGF)-I were measured. Dual energy x-ray absorptiometry (DXA) of the hip and lumbar spine was performed in two centres.Results: 3120 men, mean age 59.9 years (standard deviation [SD]=11.0) were included. After adjustment for centre, age, height, weight, lifestyle factors, season and other hormones, total and free E(2) were negatively associated with β-cTX but not P1NP while SHBG, IGF-I and PTH were positively associated with both β-cTX and P1NP. Total or free T were not independently associated with either bone marker. After the same adjustments, higher levels of both bone markers were significantly associated with lower QUS parameters and lower DXA-assessed bone density at the total hip and lumbar spine.Conclusions: Oestradiol, SHBG, IGF-I and PTH contribute significantly to the regulation / rate of bone turnover in middle-aged and older European men. Higher rates of bone remodeling are negatively associated with male bone health.
Bibliographic metadata
- Boonen, Steven
- Pye, Stephen R
- O'Neill, Terence W
- Szulc, Pawel
- Gielen, Evelien
- Borghs, Herman
- Verschueren, Sabine
- Claessens, Frank
- Adams, Judith E
- Ward, Kate A
- Bartfai, Gyorgy
- Casanueva, Felipe F
- Finn, Joseph D
- Forti, Gianni
- Giwercman, Aleksander
- Han, Thang Sieu
- Huhtaniemi, Ilpo
- Kula, Krzysztof
- Labrie, Fernand
- Lean, Michael
- Pendleton, Neil
- Punab, Margus
- Silman, Alan J
- Tajar, Abdelouahid
- Wu, Fredrick
- Vanderschueren, Dirk