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Full-text held externally
- PMID: 21296191
- UKPMCID: 21296191
- DOI: 10.1016/j.autrev.2011.01.009
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Pernicious anemia - genetic insights.
Banka, Siddharth; Ryan, Kate; Thomson, Wendy; Newman, William G
Autoimmunity reviews. 2011;10(8):455-9.
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Full-text held externally
- PMID: 21296191
- UKPMCID: 21296191
- DOI: 10.1016/j.autrev.2011.01.009
Abstract
Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA.