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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Franke, Andre; McGovern, Dermot P B; Barrett, Jeffrey C; Wang, Kai; Radford-Smith, Graham L; Ahmad, Tariq; Lees, Charlie W; Balschun, Tobias; Lee, James; Roberts, Rebecca; Anderson, Carl A; Bis, Joshua C; Bumpstead, Suzanne; Ellinghaus, David; Festen, Eleonora M; Georges, Michel; Green, Todd; Haritunians, Talin; Jostins, Luke; Latiano, Anna; Mathew, Christopher G; Montgomery, Grant W; Prescott, Natalie J; Raychaudhuri, Soumya; Rotter, Jerome I; Schumm, Philip; Sharma, Yashoda; Simms, Lisa A; Taylor, Kent D; Whiteman, David; Wijmenga, Cisca; Baldassano, Robert N; Barclay, Murray; Bayless, Theodore M; Brand, Stephan; Büning, Carsten; Cohen, Albert; Colombel, Jean-Frederick; Cottone, Mario; Stronati, Laura; Denson, Ted; De Vos, Martine; D'Inca, Renata; Dubinsky, Marla; Edwards, Cathryn; Florin, Tim; Franchimont, Denis; Gearry, Richard; Glas, Jürgen; Van Gossum, Andre; Guthery, Stephen L; Halfvarson, Jonas; Verspaget, Hein W; Hugot, Jean-Pierre; Karban, Amir; Laukens, Debby; Lawrance, Ian; Lemann, Marc; Levine, Arie; Libioulle, Cecile; Louis, Edouard; Mowat, Craig; Newman, William; Panés, Julián; Phillips, Anne; Proctor, Deborah D; Regueiro, Miguel; Russell, Richard; Rutgeerts, Paul; Sanderson, Jeremy; Sans, Miquel; Seibold, Frank; Steinhart, A Hillary; Stokkers, Pieter C F; Torkvist, Leif; Kullak-Ublick, Gerd; Wilson, David; Walters, Thomas; Targan, Stephan R; Brant, Steven R; Rioux, John D; D'Amato, Mauro; Weersma, Rinse K; Kugathasan, Subra; Griffiths, Anne M; Mansfield, John C; Vermeire, Severine; Duerr, Richard H; Silverberg, Mark S; Satsangi, Jack; Schreiber, Stefan; Cho, Judy H; Annese, Vito; Hakonarson, Hakon; Daly, Mark J; Parkes, Miles

Nature genetics. 2010;42(12):1118-25.

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Abstract

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10â»â¸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Bibliographic metadata

Type of resource:
Content type:
Journal article
Publication type:
Review article
Author(s):
Published date:
2010-12
Article title:
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Journal title:
Nature genetics
Abbreviated journal title:
Nat Genet
ISSN:
1546-1718
Place of publication:
United States
Volume:
42
Issue:
12
Pagination:
1118-25
Digital Object Identifier:
10.1038/ng.717
Pubmed Identifier:
21102463
Pii Identifier:
ng.717
Funder acknowledgement:
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:132935
Created by:
Newman, William
Created:
12th October, 2011, 14:40:15
Last modified by:
Newman, William
Last modified:
11th March, 2014, 22:54:46

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