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Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain.

Gurwitz, David; Rodríguez-Antona, Cristina; Payne, Katherine; Newman, William; Gisbert, Javier P; de Mesa, Emma Gutiérrez; Ibarreta, Dolores

European journal of human genetics : EJHG. 2009;17(8):991-8.

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Abstract

Thiopurine S-methyltransferase (TPMT) is the rate-limiting step in the conversion of thiopurine drugs including azathioprine (AZA) to inactive metabolites. Heritable deficiency of TPMT activity increases risk for adverse events, most notably, myelosuppression leading to leukopenia and neutropenic sepsis. The reported European Commission study was undertaken to identify current evidence for the clinical utility of testing for TPMT status and extent of uptake, by either genotyping or phenotyping, in the clinical setting. Data presented here for the UK and Spain indicate that there has been a considerable increase in the uptake of TPMT testing in recent years. There are some data that support routine TPMT testing before AZA prescribing for reducing AZA-related adverse events. Key data include evidence in favor of TPMT testing in addition to the current practice of routine monitoring for reducing the number of AZA-related episodes of myelosuppression, averting deaths from neutropenic sepsis and improving health-related quality of life. Further data are needed for determining the cost-effectiveness of routine TPMT testing.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
17
Issue:
8
Pagination:
991-8
Digital Object Identifier:
10.1038/ejhg.2009.10
Pubmed Identifier:
19223932
Pii Identifier:
ejhg200910
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:132938
Created by:
Newman, William
Created:
12th October, 2011, 14:40:21
Last modified by:
Newman, William
Last modified:
10th April, 2013, 20:07:35

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