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- PMID: 21297633
- UKPMCID: 21297633
- DOI: 10.1038/ng.764
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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson, Carl A; Boucher, Gabrielle; Lees, Charlie W; Franke, Andre; D'Amato, Mauro; Taylor, Kent D; Lee, James C; Goyette, Philippe; Imielinski, Marcin; Latiano, Anna; Lagacé, Caroline; Scott, Regan; Amininejad, Leila; Bumpstead, Suzannah; Baidoo, Leonard; Baldassano, Robert N; Barclay, Murray; Bayless, Theodore M; Brand, Stephan; Büning, Carsten; Colombel, Jean-Frédéric; Denson, Lee A; De Vos, Martine; Dubinsky, Marla; Edwards, Cathryn; Ellinghaus, David; Fehrmann, Rudolf S N; Floyd, James A B; Florin, Timothy; Franchimont, Denis; Franke, Lude; Georges, Michel; Glas, Jürgen; Glazer, Nicole L; Guthery, Stephen L; Haritunians, Talin; Hayward, Nicholas K; Hugot, Jean-Pierre; Jobin, Gilles; Laukens, Debby; Lawrance, Ian; Lémann, Marc; Levine, Arie; Libioulle, Cecile; Louis, Edouard; McGovern, Dermot P; Milla, Monica; Montgomery, Grant W; Morley, Katherine I; Mowat, Craig; Ng, Aylwin; Newman, William; Ophoff, Roel A; Papi, Laura; Palmieri, Orazio; Peyrin-Biroulet, Laurent; Panés, Julián; Phillips, Anne; Prescott, Natalie J; Proctor, Deborah D; Roberts, Rebecca; Russell, Richard; Rutgeerts, Paul; Sanderson, Jeremy; Sans, Miquel; Schumm, Philip; Seibold, Frank; Sharma, Yashoda; Simms, Lisa A; Seielstad, Mark; Steinhart, A Hillary; Targan, Stephan R; van den Berg, Leonard H; Vatn, Morten; Verspaget, Hein; Walters, Thomas; Wijmenga, Cisca; Wilson, David C; Westra, Harm-Jan; Xavier, Ramnik J; Zhao, Zhen Z; Ponsioen, Cyriel Y; Andersen, Vibeke; Torkvist, Leif; Gazouli, Maria; Anagnou, Nicholas P; Karlsen, Tom H; Kupcinskas, Limas; Sventoraityte, Jurgita; Mansfield, John C; Kugathasan, Subra; Silverberg, Mark S; Halfvarson, Jonas; Rotter, Jerome I; Mathew, Christopher G; Griffiths, Anne M; Gearry, Richard; Ahmad, Tariq; Brant, Steven R; Chamaillard, Mathias; Satsangi, Jack; Cho, Judy H; Schreiber, Stefan; Daly, Mark J; Barrett, Jeffrey C; Parkes, Miles; Annese, Vito; Hakonarson, Hakon; Radford-Smith, Graham; Duerr, Richard H; Vermeire, Séverine; Weersma, Rinse K; Rioux, John D
Nature genetics. 2011;43(3):246-52.
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Full-text held externally
- PMID: 21297633
- UKPMCID: 21297633
- DOI: 10.1038/ng.764
Abstract
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.
Bibliographic metadata
- Anderson, Carl A
- Boucher, Gabrielle
- Lees, Charlie W
- Franke, Andre
- D'Amato, Mauro
- Taylor, Kent D
- Lee, James C
- Goyette, Philippe
- Imielinski, Marcin
- Latiano, Anna
- Lagacé, Caroline
- Scott, Regan
- Amininejad, Leila
- Bumpstead, Suzannah
- Baidoo, Leonard
- Baldassano, Robert N
- Barclay, Murray
- Bayless, Theodore M
- Brand, Stephan
- Büning, Carsten
- Colombel, Jean-Frédéric
- Denson, Lee A
- De Vos, Martine
- Dubinsky, Marla
- Edwards, Cathryn
- Ellinghaus, David
- Fehrmann, Rudolf S N
- Floyd, James A B
- Florin, Timothy
- Franchimont, Denis
- Franke, Lude
- Georges, Michel
- Glas, Jürgen
- Glazer, Nicole L
- Guthery, Stephen L
- Haritunians, Talin
- Hayward, Nicholas K
- Hugot, Jean-Pierre
- Jobin, Gilles
- Laukens, Debby
- Lawrance, Ian
- Lémann, Marc
- Levine, Arie
- Libioulle, Cecile
- Louis, Edouard
- McGovern, Dermot P
- Milla, Monica
- Montgomery, Grant W
- Morley, Katherine I
- Mowat, Craig
- Ng, Aylwin
- Newman, William
- Ophoff, Roel A
- Papi, Laura
- Palmieri, Orazio
- Peyrin-Biroulet, Laurent
- Panés, Julián
- Phillips, Anne
- Prescott, Natalie J
- Proctor, Deborah D
- Roberts, Rebecca
- Russell, Richard
- Rutgeerts, Paul
- Sanderson, Jeremy
- Sans, Miquel
- Schumm, Philip
- Seibold, Frank
- Sharma, Yashoda
- Simms, Lisa A
- Seielstad, Mark
- Steinhart, A Hillary
- Targan, Stephan R
- van den Berg, Leonard H
- Vatn, Morten
- Verspaget, Hein
- Walters, Thomas
- Wijmenga, Cisca
- Wilson, David C
- Westra, Harm-Jan
- Xavier, Ramnik J
- Zhao, Zhen Z
- Ponsioen, Cyriel Y
- Andersen, Vibeke
- Torkvist, Leif
- Gazouli, Maria
- Anagnou, Nicholas P
- Karlsen, Tom H
- Kupcinskas, Limas
- Sventoraityte, Jurgita
- Mansfield, John C
- Kugathasan, Subra
- Silverberg, Mark S
- Halfvarson, Jonas
- Rotter, Jerome I
- Mathew, Christopher G
- Griffiths, Anne M
- Gearry, Richard
- Ahmad, Tariq
- Brant, Steven R
- Chamaillard, Mathias
- Satsangi, Jack
- Cho, Judy H
- Schreiber, Stefan
- Daly, Mark J
- Barrett, Jeffrey C
- Parkes, Miles
- Annese, Vito
- Hakonarson, Hakon
- Radford-Smith, Graham
- Duerr, Richard H
- Vermeire, Séverine
- Weersma, Rinse K
- Rioux, John D
- 083948/Z/07/Z, Wellcome Trust, United Kingdom
- AI062773, NIAID NIH HHS, United States
- DK 063491, NIDDK NIH HHS, United States
- DK043351, NIDDK NIH HHS, United States
- DK062413, NIDDK NIH HHS, United States
- DK062420, NIDDK NIH HHS, United States
- DK062422, NIDDK NIH HHS, United States
- DK062423, NIDDK NIH HHS, United States
- DK062429, NIDDK NIH HHS, United States
- DK062431, NIDDK NIH HHS, United States
- DK062432, NIDDK NIH HHS, United States
- DK064869, NIDDK NIH HHS, United States
- DK069513, NIDDK NIH HHS, United States
- DK076984, NIDDK NIH HHS, United States
- DK084554, NIDDK NIH HHS, United States
- DK83756, NIDDK NIH HHS, United States
- M01-RR00425, NCRR NIH HHS, United States
- P01-DK046763, NIDDK NIH HHS, United States
- R01 DK060049-10, NIDDK NIH HHS, United States
- R01 DK064869-05S1, NIDDK NIH HHS, United States
- R01 DK064869-06A1, NIDDK NIH HHS, United States
- R01 DK064869-07, NIDDK NIH HHS, United States
- R01 DK064869-08, NIDDK NIH HHS, United States
- R01 DK064869-09, NIDDK NIH HHS, United States
- R01 DK083756-04, NIDDK NIH HHS, United States
- U01 DK062432-07, NIDDK NIH HHS, United States
- U01 DK062432-08, NIDDK NIH HHS, United States
- U01 DK062432-09, NIDDK NIH HHS, United States
- U01 DK062432-10, NIDDK NIH HHS, United States
- WT089120/Z/09/Z, Wellcome Trust, United Kingdom
- WT091745/Z/10/Z, Wellcome Trust, United Kingdom
- , Medical Research Council, United Kingdom