Related resources
Full-text held externally
- DOI: 10.1093/rheumatology/ker259
- PMID: 21875883
- UKPMCID: 21875883
Search for item elsewhere
University researcher(s)
Academic department(s)
Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.
Bossini-Castillo, Lara; Simeon, Carmen P; Beretta, Lorenzo; Vonk, Madelon C; Callejas-Rubio, José Luis; Espinosa, Gerard; Carreira, Patricia; Camps, MarÃa T; RodrÃguez-RodrÃguez, Luis; RodrÃguez-Carballeira, Mónica; GarcÃa-Hernández, Francisco J; López-Longo, Francisco J; Hernández-Hernández, Vanesa; Sáez-Comet, Luis; Egurbide, MarÃa Victoria; Hesselstrand, Roger; Nordin, Annika; Hoffmann-Vold, Anna-Maria; Vanthuyne, Marie; Smith, Vanessa; De Langhe, Ellen; Kreuter, Alexander; Riemekasten, Gabriela; Witte, Torsten; Hunzelmann, Nicolas; Voskuyl, Alexandre E; Schuerwegh, Annemie J; Lunardi, Claudio; Airó, Paolo; Scorza, Raffaella; Shiels, Paul; van Laar, Jacob M; Fonseca, Carmen; Denton, Christopher; Herrick, Ariane; Worthington, Jane; Koeleman, Bobby P; Rueda, Blanca; Radstake, Timothy R D J; Martin, Javier
Rheumatology (Oxford, England). 2011;50(11):1976-1981.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1093/rheumatology/ker259
- PMID: 21875883
- UKPMCID: 21875883
Abstract
Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population. Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (SNP) was selected as genetic marker and genotyped using Taqman 5' allelic discrimination assay. Results. The MIF -173 SNP showed association with SSc [P = 0.04, odds ratio (OR) = 1.10, 95% CI 1.00, 1.19]. Analysis of the MIF -173 polymorphism according to SSc clinical phenotype revealed that the frequency of the -173*C allele was significantly higher in the dcSSc group compared with controls (P = 5.30E-03, OR = 1.21, 95% CI 1.07, 1.38). Conversely, the frequency of the MIF -173*C allele was significantly underrepresented in the lcSSc group compared with dcSSc patients, supporting previous findings [(P = 0.04, OR = 0.86, 95% CI 0.75, 0.99); meta-analysis including previous results (P = 0.005, OR = 0.83, 95% CI 0.73, 0.94)]. Conclusion. Our results confirm the role of MIF -173 promoter polymorphism in SSc, and provide evidence of a strong association with the dcSSc subgroup of patients. Hence, the MIF -173 variant is confirmed as a promising clinical phenotype genetic marker.
Bibliographic metadata
- Bossini-Castillo, Lara
- Simeon, Carmen P
- Beretta, Lorenzo
- Vonk, Madelon C
- Callejas-Rubio, José Luis
- Espinosa, Gerard
- Carreira, Patricia
- Camps, MarÃa T
- RodrÃguez-RodrÃguez, Luis
- RodrÃguez-Carballeira, Mónica
- GarcÃa-Hernández, Francisco J
- López-Longo, Francisco J
- Hernández-Hernández, Vanesa
- Sáez-Comet, Luis
- Egurbide, MarÃa Victoria
- Hesselstrand, Roger
- Nordin, Annika
- Hoffmann-Vold, Anna-Maria
- Vanthuyne, Marie
- Smith, Vanessa
- De Langhe, Ellen
- Kreuter, Alexander
- Riemekasten, Gabriela
- Witte, Torsten
- Hunzelmann, Nicolas
- Voskuyl, Alexandre E
- Schuerwegh, Annemie J
- Lunardi, Claudio
- Airó, Paolo
- Scorza, Raffaella
- Shiels, Paul
- van Laar, Jacob M
- Fonseca, Carmen
- Denton, Christopher
- Herrick, Ariane
- Worthington, Jane
- Koeleman, Bobby P
- Rueda, Blanca
- Radstake, Timothy R D J
- Martin, Javier