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Intracranial calcification in early infantile Krabbe disease: nothing new under the sun.

Livingston, John H; Graziano, Claudio; Pysden, Karen; Crow, Yanick J; Mordekar, Santosh R; Moroni, Isabella; Uziel, Graziella

Developmental medicine and child neurology. 2011;.

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Abstract

We report the cases of three children, one male and two females, with a diagnosis of early infantile Krabbe disease demonstrating intracranial calcification on computed tomography (CT). The pattern of calcification was similar in all individuals and involved the internal capsule and cerebral white matter. The presence of calcification caused some diagnostic confusion in what was otherwise a typical clinical and radiological presentation. This finding is not new and has previously been described in publications from the 1980s and 1990s reporting the CT and magnetic resonance imaging appearances of Krabbe disease. With increasing use of magnetic resonance as the first imaging modality for investigation of neurological disorders, characteristic CT appearances may be forgotten. This report serves as a reminder that Krabbe disease should be included in the differential diagnosis of disorders causing intracranial calcification.

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Digital Object Identifier:
10.1111/j.1469-8749.2011.04167.x
Pubmed Identifier:
22150413
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:146559
Created by:
Crow, Yanick
Created:
9th January, 2012, 19:07:32
Last modified by:
Crow, Yanick
Last modified:
9th January, 2012, 19:07:32

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