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Perfusion SPECT and FDG-PET

Herholz, K

Int Psychogeriatr. 2011;:1-7.

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Abstract

ABSTRACTBoth perfusion SPECT and FDG-PET provide images that closely reflect neuronal activity. There is a characteristic regional impairment in Alzheimer's disease (AD) that involves mainly the temporo-parietal association cortices, mesial temporal structures and to a more variable degree also the frontal association cortex. This pattern of functional impairment can provide a biomarker for diagnosis of AD and other neurodegenerative dementias at the clinical stage of mild cognitive impairment, and for monitoring of progression. FDG-PET is quantitatively more accurate and thus better suited to multicenter studies than perfusion SPECT. Regional metabolic and blood flow changes are closely related to clinical symptoms, and most areas involved in these changes will also develop significant cortical atrophy. FDG-PET is complementary to amyloid PET, which targets a molecular marker that does not have a close relation to current symptoms. Current restrictions in the availability and cost of FDG-PET are being reduced, as oncological FDG-PET is being adopted as a standard clinical service in most countries. Limitations in the availability of trained staff should be overcome by training programs set up by professional organizations. Against the background of the development of new criteria for diagnosing AD before the onset of dementia, FDG-PET is expected to play an increasing role in diagnosing patients at an early stage of AD and in clinical trials of drugs aimed at preventing or delaying the onset of dementia.

Bibliographic metadata

Type of resource:
Content type:
Author(s):
Published date:
Language:
eng
Journal title:
Start page:
1
End page:
7
Total:
7
Pagination:
1-7
Digital Object Identifier:
S1041610211000937 [pii] 10.1017/S1041610211000937
ISI Accession Number:
21729421
Related website(s):
  • Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21729421
General notes:
  • Journal article International psychogeriatrics / IPA Int Psychogeriatr. 2011 Jun 10:1-7.
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:153911
Created by:
Herholz, Karl
Created:
25th January, 2012, 10:37:15
Last modified by:
Herholz, Karl
Last modified:
25th January, 2012, 10:37:15

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