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Effectiveness and Safety of 18F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature

Bohnen, N I; Djang, D S; Herholz, K; Anzai, Y; Minoshima, S

J Nucl Med. 2012;53(1):59-71.

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Abstract

Imaging that can detect pathophysiologic change in the brain holds great promise for diagnostic assessment of patients with Alzheimer disease (AD) and dementia. Although a previous metaanalysis centering on literature from 1990 to 2000 showed a summary accuracy of 86% for (18)F-FDG PET for AD diagnosis, the clinical value was considered uncertain because of methodologic shortcomings. Review of the recent literature since 2000 demonstrates that the evidence for (18)F-FDG PET in assessment of dementia has increased with new studies that include autopsy confirmation, wide-diagnostic-spectrum recruitment in primary care settings, historical and prospective cohort studies, and multicenter data analyses. These data support the role of (18)F-FDG PET as an effective and useful adjunct to other diagnostic information in the assessment of patients with symptoms of dementia. Findings are in line with recently revised diagnostic criteria of AD that for the first time recognize the unique role of biomarker evidence in disease definition.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Language:
eng
Journal title:
Volume:
53
Issue:
1
Start page:
59
End page:
71
Total:
13
Pagination:
59-71
Digital Object Identifier:
jnumed.111.096578 [pii] 10.2967/jnumed.111.096578
ISI Accession Number:
22173840
Related website(s):
  • Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22173840
General notes:
  • Bohnen, Nicolaas I Djang, David S W Herholz, Karl Anzai, Yoshimi Minoshima, Satoshi United States Journal of nuclear medicine : official publication, Society of Nuclear Medicine J Nucl Med. 2012 Jan;53(1):59-71. Epub 2011 Dec 15.
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:153916
Created by:
Herholz, Karl
Created:
25th January, 2012, 10:37:15
Last modified by:
Herholz, Karl
Last modified:
25th January, 2012, 10:37:15

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