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- DOI: 10.1210/jc.2011-2513
- PMID: 22419720
- UKPMCID: 22419720
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Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS).
Tajar, Abdelouahid; Huhtaniemi, Ilpo T; O'Neill, Terence W; Finn, Joseph D; Pye, Stephen R; Lee, David M; Bartfai, György; Boonen, Steven; Casanueva, Felipe F F; Forti, Gianni; Giwercman, Aleksander; Han, Thang S; Kula, Krzysztof; Labrie, Fernand; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Vanderschueren, Dirk; Wu, Frederick C W; EMAS_Group
The Journal of clinical endocrinology and metabolism. 2012;97(5):1508-1516.
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Full-text held externally
- DOI: 10.1210/jc.2011-2513
- PMID: 22419720
- UKPMCID: 22419720
Abstract
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T).Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria.Design, Setting, and Participants:The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79 years in eight European countries.Main Outcome Measure(s):Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured.Results:Sixty-three men (2.1%) were classified as having LOH: 36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points.Conclusions:LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter.
Bibliographic metadata
- Tajar, Abdelouahid
- Huhtaniemi, Ilpo T
- O'Neill, Terence W
- Finn, Joseph D
- Pye, Stephen R
- Lee, David M
- Bartfai, György
- Boonen, Steven
- Casanueva, Felipe F F
- Forti, Gianni
- Giwercman, Aleksander
- Han, Thang S
- Kula, Krzysztof
- Labrie, Fernand
- Lean, Michael E J
- Pendleton, Neil
- Punab, Margus
- Vanderschueren, Dirk
- Wu, Frederick C W
- EMAS_Group