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IL-10: the master regulator of immunity to infection.

Couper, Kevin N; Blount, Daniel G; Riley, Eleanor M

Journal of immunology (Baltimore, Md. : 1950). 2008;180(9):5771-7.

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Abstract

IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology. Many different types of cells can produce IL-10, with the major source of IL-10 varying in different tissues or during acute or chronic stages of the same infection. The priming of these various IL-10-producing populations during infections is not well understood and it is not clear whether the cellular source of IL-10 during infection dictates its cellular target and thus its outcome. In this article we review the biology of IL-10, its cellular sources, and its role in viral, bacterial, and protozoal infections.

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Type of resource:
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Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
180
Issue:
9
Pagination:
5771-7
Pubmed Identifier:
18424693
Pii Identifier:
180/9/5771
Access state:
Active

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University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:158629
Created by:
Couper, Kevin
Created:
6th April, 2012, 11:18:31
Last modified by:
Couper, Kevin
Last modified:
14th February, 2016, 20:20:21

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