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- DOI: 10.1038/ng.2231
- PMID: 22446963
- UKPMCID: 22446963
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Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Okada, Yukinori; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Kawaguchi, Takahisa; Stahl, Eli A; Kurreeman, Fina A S; Nishida, Nao; Ohmiya, Hiroko; Myouzen, Keiko; Takahashi, Meiko; Sawada, Tetsuji; Nishioka, Yuichi; Yukioka, Masao; Matsubara, Tsukasa; Wakitani, Shigeyuki; Teshima, Ryota; Tohma, Shigeto; Takasugi, Kiyoshi; Shimada, Kota; Murasawa, Akira; Honjo, Shigeru; Matsuo, Keitaro; Tanaka, Hideo; Tajima, Kazuo; Suzuki, Taku; Iwamoto, Takuji; Kawamura, Yoshiya; Tanii, Hisashi; Okazaki, Yuji; Sasaki, Tsukasa; Gregersen, Peter K; Padyukov, Leonid; Worthington, Jane; Siminovitch, Katherine A; Lathrop, Mark; Taniguchi, Atsuo; Takahashi, Atsushi; Tokunaga, Katsushi; Kubo, Michiaki; Nakamura, Yusuke; Kamatani, Naoyuki; Mimori, Tsuneyo; Plenge, Robert M; Yamanaka, Hisashi; Momohara, Shigeki; Yamada, Ryo; Matsuda, Fumihiko; Yamamoto, Kazuhiko
Nature genetics. 2012;44(5):511-516.
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Full-text held externally
- DOI: 10.1038/ng.2231
- PMID: 22446963
- UKPMCID: 22446963
Abstract
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 Ă— 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves' disease (P = 3.5 Ă— 10(-4) and 2.9 Ă— 10(-4), respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.
Bibliographic metadata
- Okada, Yukinori
- Terao, Chikashi
- Ikari, Katsunori
- Kochi, Yuta
- Ohmura, Koichiro
- Suzuki, Akari
- Kawaguchi, Takahisa
- Stahl, Eli A
- Kurreeman, Fina A S
- Nishida, Nao
- Ohmiya, Hiroko
- Myouzen, Keiko
- Takahashi, Meiko
- Sawada, Tetsuji
- Nishioka, Yuichi
- Yukioka, Masao
- Matsubara, Tsukasa
- Wakitani, Shigeyuki
- Teshima, Ryota
- Tohma, Shigeto
- Takasugi, Kiyoshi
- Shimada, Kota
- Murasawa, Akira
- Honjo, Shigeru
- Matsuo, Keitaro
- Tanaka, Hideo
- Tajima, Kazuo
- Suzuki, Taku
- Iwamoto, Takuji
- Kawamura, Yoshiya
- Tanii, Hisashi
- Okazaki, Yuji
- Sasaki, Tsukasa
- Gregersen, Peter K
- Padyukov, Leonid
- Worthington, Jane
- Siminovitch, Katherine A
- Lathrop, Mark
- Taniguchi, Atsuo
- Takahashi, Atsushi
- Tokunaga, Katsushi
- Kubo, Michiaki
- Nakamura, Yusuke
- Kamatani, Naoyuki
- Mimori, Tsuneyo
- Plenge, Robert M
- Yamanaka, Hisashi
- Momohara, Shigeki
- Yamada, Ryo
- Matsuda, Fumihiko
- Yamamoto, Kazuhiko