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The variation of function across the human insula mirrors its patterns of structural connectivity: evidence from in vivo probabilistic tractography.

Cloutman, Lauren L; Binney, Richard J; Drakesmith, Mark; Parker, Geoffrey J M; Lambon Ralph, Matthew A

NeuroImage. 2012;59(4):3514-21.

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Abstract

The human insula is a functionally complex yet poorly understood region of the cortex, implicated in a wide range of cognitive, motor, emotion and somatosensory activity. To elucidate the functional role of the insula, the current study used in vivo probabilistic tractography to map the structural connectivity of seven anatomically-defined insular subregions. The connectivity patterns identified reveal two complementary insular networks connected via a dual route architecture, and provide key insights about the neural basis of the numerous functions ascribed to this area. Specifically, anterior-most insular regions were associated with a ventrally-based network involving orbital/inferior frontal and anterior/polar temporal regions, forming part of a key emotional salience and cognitive control network associated with the implementation of goal-directed behavior. The posterior and dorsal-middle insular regions were associated with a network focused on posterior and (to a lesser extent) anterior temporal regions via both dorsal and ventral pathways. This is consistent with the involvement of the insula in sound-to-speech transformations, with an implicated role in the temporal resolution, sequencing, and feedback processes crucial for auditory and motor processing, and the monitoring and adjustment of expressive performance.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
59
Issue:
4
Pagination:
3514-21
Digital Object Identifier:
10.1016/j.neuroimage.2011.11.016
Pubmed Identifier:
22100771
Pii Identifier:
S1053-8119(11)01297-3
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:163336
Created by:
Lambon Ralph, Matthew
Created:
22nd June, 2012, 18:37:56
Last modified by:
Lambon Ralph, Matthew
Last modified:
22nd June, 2012, 18:39:51

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