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- DOI: 10.1002/art.34594
- PMID: 22736267
- UKPMCID: 22736267
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Individual MRI and radiographic features of knee OA in subjects with unilateral knee pain: Health ABC study.
Javaid, M K; Kiran, A; Guermazi, A; Kwoh, K; Zaim, S; Carbone, L; Harris, T; McCulloch, C E; Arden, N K; Lane, N E; Felson, D; Nevitt, M
Arthritis and rheumatism. 2012;64(10):3246-3255.
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Full-text held externally
- DOI: 10.1002/art.34594
- PMID: 22736267
- UKPMCID: 22736267
Abstract
Strong associations between radiographic features of knee OA and pain have been demonstrated in persons with unilateral knee symptoms. Our objectives were to compare radiographic with MRI features of knee OA and assess the discrimination between painful and non-painful knees in persons with unilateral symptoms. 283 individuals with unilateral knee pain aged 71 to 80 years from Health ABC, a study of weight-related diseases and mobility, had bilateral knee radiographs, read for KL grade and individual radiographic features, and 1.5T MRIs, read using WORMS. The association of structural features with pain was assessed using a within-person case/control design and conditional logistic regression. Receiver operator characteristics (ROC) were then used to test the discriminatory performance of structural features. In conditional logistic analyses, knee pain was significantly associated with both radiographic (any JSN grade >=1: OR 3.20 (1.79 - 5.71) and MRI (any cartilage defect:>=2: OR 3.67 (1.49 - 9.04)) features. However, most subjects had MR detected osteophytes, cartilage and bone marrow lesions in both knees and no individual structural feature discriminated well between painful and non-painful knees using ROC. The best performing MRI feature (synovitis/effusion) was not significantly more informative than KL grade >=2 (p=0.42). In persons with unilateral knee pain, MR and radiographic features were associated with knee pain confirming an important role in the etiology of pain. However, no single MRI or radiographic finding performed well in discriminating painful from non-painful knees. Further work is needed to examine how structural and non-structural factors influence knee pain.