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Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization.

Ansell, David M; Kloepper, Jennifer E; Thomason, Helen A; Paus, Ralf; Hardman, Matthew J

The Journal of investigative dermatology. 2011;131(2):518-28.

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Abstract

When the skin is damaged, a variety of cell types must migrate, proliferate, and differentiate to reform a functional barrier to the external environment. Recent studies have shown that progenitor cells residing in hair follicles (HFs) are able to contribute to this re-epithelialization of wounds in vivo. However, the influence of the hair cycle on wound healing has not previously been addressed. Here, we have exploited spontaneous postnatal hair-cycle synchronicity in mice to systematically examine the influence of the different hair-cycle stages on murine skin wound healing. We report significant acceleration of healing during the anagen phase of HF cycling in vivo, associated with alterations in epithelial, endothelial, and inflammatory cell types. Intriguingly, gene profiling data reveal a clear correlation between the transcription of genes beneficial for wound healing and those upregulated during the anagen phase of the hair cycle in unwounded skin. These findings, which demonstrate a previously unappreciated association between HF cycling and wound healing, reveal numerous molecular correlates for further investigation.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
131
Issue:
2
Pagination:
518-28
Digital Object Identifier:
10.1038/jid.2010.291
Pubmed Identifier:
20927125
Pii Identifier:
jid2010291
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:169069
Created by:
Paus, Ralf
Created:
12th September, 2012, 13:36:51
Last modified by:
Paus, Ralf
Last modified:
12th September, 2012, 13:36:51

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