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Full-text held externally
- DOI: 10.1038/ng.2383
- PMID: 22885922
- UKPMCID: 22885922
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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
The_DIAbetes_Genetics_Replication_And_Meta-analysis_(DIAGRAM)_Consortium; Morris, Andrew P; Voight, Benjamin F; Teslovich, Tanya M; Ferreira, Teresa; Segrè, Ayellet V; Steinthorsdottir, Valgerdur; Strawbridge, Rona J; Khan, Hassan; Grallert, Harald; Mahajan, Anubha; Prokopenko, Inga; Kang, Hyun Min; Dina, Christian; Esko, Tonu; Fraser, Ross M; Kanoni, Stavroula; Kumar, Ashish; Lagou, Vasiliki; Langenberg, Claudia; Luan, Jian'an; Lindgren, Cecilia M; Müller-Nurasyid, Martina; Pechlivanis, Sonali; Rayner, N William; Scott, Laura J; Wiltshire, Steven; Yengo, Loic; Kinnunen, Leena; Rossin, Elizabeth J; Raychaudhuri, Soumya; Johnson, Andrew D; Dimas, Antigone S; Loos, Ruth J F; Vedantam, Sailaja; Chen, Han; Florez, Jose C; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Couper, David J; Kao, Wen Hong L; Li, Man; Cornelis, Marilyn C; Kraft, Peter; Sun, Qi; van Dam, Rob M; Stringham, Heather M; Chines, Peter S; Fischer, Krista; Fontanillas, Pierre; Holmen, Oddgeir L; Hunt, Sarah E; Jackson, Anne U; Kong, Augustine; Lawrence, Robert; Meyer, Julia; Perry, John R B; Platou, Carl G P; Potter, Simon; Rehnberg, Emil; Robertson, Neil; Sivapalaratnam, Suthesh; Stančáková, Alena; Stirrups, Kathleen; Thorleifsson, Gudmar; Tikkanen, Emmi; Wood, Andrew R; Almgren, Peter; Atalay, Mustafa; Benediktsson, Rafn; Bonnycastle, Lori L; Burtt, Noël; Carey, Jason; Charpentier, Guillaume; Crenshaw, Andrew T; Doney, Alex S F; Dorkhan, Mozhgan; Edkins, Sarah; Emilsson, Valur; Eury, Elodie; Forsen, Tom; Gertow, Karl; Gigante, Bruna; Grant, George B; Groves, Christopher J; Guiducci, Candace; Herder, Christian; Hreidarsson, Astradur B; Hui, Jennie; James, Alan; Jonsson, Anna; Rathmann, Wolfgang; Klopp, Norman; Kravic, Jasmina; Krjutškov, Kaarel; Langford, Cordelia; Leander, Karin; Lindholm, Eero; Lobbens, Stéphane; Männistö, Satu; Mirza, Ghazala; Mühleisen, Thomas W; Musk, Bill; Parkin, Melissa; Rallidis, Loukianos; Saramies, Jouko; Sennblad, Bengt; Shah, Sonia; Sigurðsson, Gunnar; Silveira, Angela; Steinbach, Gerald; Thorand, Barbara; Trakalo, Joseph; Veglia, Fabrizio; Wennauer, Roman; Winckler, Wendy; Zabaneh, Delilah; Campbell, Harry; van Duijn, Cornelia; Uitterlinden, Andre G; Hofman, Albert; Sijbrands, Eric; Abecasis, Goncalo R; Owen, Katharine R; Zeggini, Eleftheria; Trip, Mieke D; Forouhi, Nita G; Syvänen, Ann-Christine; Eriksson, Johan G; Peltonen, Leena; Nöthen, Markus M; Balkau, Beverley; Palmer, Colin N A; Lyssenko, Valeriya; Tuomi, Tiinamaija; Isomaa, Bo; Hunter, David J; Qi, Lu; Shuldiner, Alan R; Roden, Michael; Barroso, Ines; Wilsgaard, Tom; Beilby, John; Hovingh, Kees; Price, Jackie F; Wilson, James F; Rauramaa, Rainer; Lakka, Timo A; Lind, Lars; Dedoussis, George; Njølstad, Inger; Pedersen, Nancy L; Khaw, Kay-Tee; Wareham, Nicholas J; Keinanen-Kiukaanniemi, Sirkka M; Saaristo, Timo E; Korpi-Hyövälti, Eeva; Saltevo, Juha; Laakso, Markku; Kuusisto, Johanna; Metspalu, Andres; Collins, Francis S; Mohlke, Karen L; Bergman, Richard N; Tuomilehto, Jaakko; Boehm, Bernhard O; Gieger, Christian; Hveem, Kristian; Cauchi, Stephane; Froguel, Philippe; Baldassarre, Damiano; Tremoli, Elena; Humphries, Steve E; Saleheen, Danish; Danesh, John; Ingelsson, Erik; Ripatti, Samuli; Salomaa, Veikko; Erbel, Raimund; Jöckel, Karl-Heinz; Moebus, Susanne; Peters, Annette; Illig, Thomas; de Faire, Ulf; Hamsten, Anders; Morris, Andrew D; Donnelly, Peter J; Frayling, Timothy M; Hattersley, Andrew T; Boerwinkle, Eric; Melander, Olle; Kathiresan, Sekar; Nilsson, Peter M; Deloukas, Panos; Thorsteinsdottir, Unnur; Groop, Leif C; Stefansson, Kari; Hu, Frank; Pankow, James S; Dupuis, Josée; Meigs, James B; Altshuler, David; Boehnke, Michael; McCarthy, Mark I
Nature genetics. 2012;44(9):981-990.
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Full-text held externally
- DOI: 10.1038/ng.2383
- PMID: 22885922
- UKPMCID: 22885922
Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
Bibliographic metadata
- The_DIAbetes_Genetics_Replication_And_Meta-analysis_(DIAGRAM)_Consortium
- Morris, Andrew P
- Voight, Benjamin F
- Teslovich, Tanya M
- Ferreira, Teresa
- Segrè, Ayellet V
- Steinthorsdottir, Valgerdur
- Strawbridge, Rona J
- Khan, Hassan
- Grallert, Harald
- Mahajan, Anubha
- Prokopenko, Inga
- Kang, Hyun Min
- Dina, Christian
- Esko, Tonu
- Fraser, Ross M
- Kanoni, Stavroula
- Kumar, Ashish
- Lagou, Vasiliki
- Langenberg, Claudia
- Luan, Jian'an
- Lindgren, Cecilia M
- MĂĽller-Nurasyid, Martina
- Pechlivanis, Sonali
- Rayner, N William
- Scott, Laura J
- Wiltshire, Steven
- Yengo, Loic
- Kinnunen, Leena
- Rossin, Elizabeth J
- Raychaudhuri, Soumya
- Johnson, Andrew D
- Dimas, Antigone S
- Loos, Ruth J F
- Vedantam, Sailaja
- Chen, Han
- Florez, Jose C
- Fox, Caroline
- Liu, Ching-Ti
- Rybin, Denis
- Couper, David J
- Kao, Wen Hong L
- Li, Man
- Cornelis, Marilyn C
- Kraft, Peter
- Sun, Qi
- van Dam, Rob M
- Stringham, Heather M
- Chines, Peter S
- Fischer, Krista
- Fontanillas, Pierre
- Holmen, Oddgeir L
- Hunt, Sarah E
- Jackson, Anne U
- Kong, Augustine
- Lawrence, Robert
- Meyer, Julia
- Perry, John R B
- Platou, Carl G P
- Potter, Simon
- Rehnberg, Emil
- Robertson, Neil
- Sivapalaratnam, Suthesh
- Stančáková, Alena
- Stirrups, Kathleen
- Thorleifsson, Gudmar
- Tikkanen, Emmi
- Wood, Andrew R
- Almgren, Peter
- Atalay, Mustafa
- Benediktsson, Rafn
- Bonnycastle, Lori L
- Burtt, Noël
- Carey, Jason
- Charpentier, Guillaume
- Crenshaw, Andrew T
- Doney, Alex S F
- Dorkhan, Mozhgan
- Edkins, Sarah
- Emilsson, Valur
- Eury, Elodie
- Forsen, Tom
- Gertow, Karl
- Gigante, Bruna
- Grant, George B
- Groves, Christopher J
- Guiducci, Candace
- Herder, Christian
- Hreidarsson, Astradur B
- Hui, Jennie
- James, Alan
- Jonsson, Anna
- Rathmann, Wolfgang
- Klopp, Norman
- Kravic, Jasmina
- Krjutškov, Kaarel
- Langford, Cordelia
- Leander, Karin
- Lindholm, Eero
- Lobbens, Stéphane
- Männistö, Satu
- Mirza, Ghazala
- MĂĽhleisen, Thomas W
- Musk, Bill
- Parkin, Melissa
- Rallidis, Loukianos
- Saramies, Jouko
- Sennblad, Bengt
- Shah, Sonia
- SigurĂ°sson, Gunnar
- Silveira, Angela
- Steinbach, Gerald
- Thorand, Barbara
- Trakalo, Joseph
- Veglia, Fabrizio
- Wennauer, Roman
- Winckler, Wendy
- Zabaneh, Delilah
- Campbell, Harry
- van Duijn, Cornelia
- Uitterlinden, Andre G
- Hofman, Albert
- Sijbrands, Eric
- Abecasis, Goncalo R
- Owen, Katharine R
- Zeggini, Eleftheria
- Trip, Mieke D
- Forouhi, Nita G
- Syvänen, Ann-Christine
- Eriksson, Johan G
- Peltonen, Leena
- Nöthen, Markus M
- Balkau, Beverley
- Palmer, Colin N A
- Lyssenko, Valeriya
- Tuomi, Tiinamaija
- Isomaa, Bo
- Hunter, David J
- Qi, Lu
- Shuldiner, Alan R
- Roden, Michael
- Barroso, Ines
- Wilsgaard, Tom
- Beilby, John
- Hovingh, Kees
- Price, Jackie F
- Wilson, James F
- Rauramaa, Rainer
- Lakka, Timo A
- Lind, Lars
- Dedoussis, George
- Njølstad, Inger
- Pedersen, Nancy L
- Khaw, Kay-Tee
- Wareham, Nicholas J
- Keinanen-Kiukaanniemi, Sirkka M
- Saaristo, Timo E
- Korpi-Hyövälti, Eeva
- Saltevo, Juha
- Laakso, Markku
- Kuusisto, Johanna
- Metspalu, Andres
- Collins, Francis S
- Mohlke, Karen L
- Bergman, Richard N
- Tuomilehto, Jaakko
- Boehm, Bernhard O
- Gieger, Christian
- Hveem, Kristian
- Cauchi, Stephane
- Froguel, Philippe
- Baldassarre, Damiano
- Tremoli, Elena
- Humphries, Steve E
- Saleheen, Danish
- Danesh, John
- Ingelsson, Erik
- Ripatti, Samuli
- Salomaa, Veikko
- Erbel, Raimund
- Jöckel, Karl-Heinz
- Moebus, Susanne
- Peters, Annette
- Illig, Thomas
- de Faire, Ulf
- Hamsten, Anders
- Morris, Andrew D
- Donnelly, Peter J
- Frayling, Timothy M
- Hattersley, Andrew T
- Boerwinkle, Eric
- Melander, Olle
- Kathiresan, Sekar
- Nilsson, Peter M
- Deloukas, Panos
- Thorsteinsdottir, Unnur
- Groop, Leif C
- Stefansson, Kari
- Hu, Frank
- Pankow, James S
- Dupuis, Josée
- Meigs, James B
- Altshuler, David
- Boehnke, Michael
- McCarthy, Mark I