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Full-text held externally
- DOI: 10.1038/ng.609
- PMID: 20581827
- UKPMCID: 20581827
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Voight, Benjamin F; Scott, Laura J; Steinthorsdottir, Valgerdur; Morris, Andrew P; Dina, Christian; Welch, Ryan P; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S; Thorleifsson, Gudmar; McCulloch, Laura J; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen J; Raychaudhuri, Soumya; McCarroll, Steve A; Langenberg, Claudia; Hofmann, Oliver M; Dupuis, Josée; Qi, Lu; Segrè, Ayellet V; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Rafn; Bennett, Amanda J; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lori L; Bengtsson Boström, Kristina; Bravenboer, Bert; Bumpstead, Suzannah; Burtt, Noisël P; Charpentier, Guillaume; Chines, Peter S; Cornelis, Marilyn; Couper, David J; Crawford, Gabe; Doney, Alex S F; Elliott, Katherine S; Elliott, Amanda L; Erdos, Michael R; Fox, Caroline S; Franklin, Christopher S; Ganser, Martha; Gieger, Christian; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christopher J; Guiducci, Candace; Hadjadj, Samy; Hassanali, Neelam; Herder, Christian; Isomaa, Bo; Jackson, Anne U; Johnson, Paul R V; Jørgensen, Torben; Kao, Wen H L; Klopp, Norman; Kong, Augustine; Kraft, Peter; Kuusisto, Johanna; Lauritzen, Torsten; Li, Man; Lieverse, Aloysius; Lindgren, Cecilia M; Lyssenko, Valeriya; Marre, Michel; Meitinger, Thomas; Midthjell, Kristian; Morken, Mario A; Narisu, Narisu; Nilsson, Peter; Owen, Katharine R; Payne, Felicity; Perry, John R B; Petersen, Ann-Kristin; Platou, Carl; Proença, Christine; Prokopenko, Inga; Rathmann, Wolfgang; Rayner, N William; Robertson, Neil R; Rocheleau, Ghislain; Roden, Michael; Sampson, Michael J; Saxena, Richa; Shields, Beverley M; Shrader, Peter; Sigurdsson, Gunnar; Sparsø, Thomas; Strassburger, Klaus; Stringham, Heather M; Sun, Qi; Swift, Amy J; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaija; van Dam, Rob M; van Haeften, Timon W; van Herpt, Thijs; van Vliet-Ostaptchouk, Jana V; Walters, G Bragi; Weedon, Michael N; Wijmenga, Cisca; Witteman, Jacqueline; Bergman, Richard N; Cauchi, Stephane; Collins, Francis S; Gloyn, Anna L; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A; Hitman, Graham A; Hofman, Albert; Hunter, David J; Hveem, Kristian; Laakso, Markku; Mohlke, Karen L; Morris, Andrew D; Palmer, Colin N A; Pramstaller, Peter P; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D; Tuomilehto, Jaakko; Uitterlinden, Andre; Walker, Mark; Wareham, Nicholas J; Watanabe, Richard M; Abecasis, Gonçalo R; Boehm, Bernhard O; Campbell, Harry; Daly, Mark J; Hattersley, Andrew T; Hu, Frank B; Meigs, James B; Pankow, James S; Pedersen, Oluf; Wichmann, H-Erich; Barroso, Inês; Florez, Jose C; Frayling, Timothy M; Groop, Leif; Sladek, Rob; Thorsteinsdottir, Unnur; Wilson, James F; Illig, Thomas; Froguel, Philippe; van Duijn, Cornelia M; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I
Nature genetics. 2010;42(7):579-89.
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Full-text held externally
- DOI: 10.1038/ng.609
- PMID: 20581827
- UKPMCID: 20581827
Abstract
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
Bibliographic metadata
- Voight, Benjamin F
- Scott, Laura J
- Steinthorsdottir, Valgerdur
- Morris, Andrew P
- Dina, Christian
- Welch, Ryan P
- Zeggini, Eleftheria
- Huth, Cornelia
- Aulchenko, Yurii S
- Thorleifsson, Gudmar
- McCulloch, Laura J
- Ferreira, Teresa
- Grallert, Harald
- Amin, Najaf
- Wu, Guanming
- Willer, Cristen J
- Raychaudhuri, Soumya
- McCarroll, Steve A
- Langenberg, Claudia
- Hofmann, Oliver M
- Dupuis, Josée
- Qi, Lu
- Segrè, Ayellet V
- van Hoek, Mandy
- Navarro, Pau
- Ardlie, Kristin
- Balkau, Beverley
- Benediktsson, Rafn
- Bennett, Amanda J
- Blagieva, Roza
- Boerwinkle, Eric
- Bonnycastle, Lori L
- Bengtsson Boström, Kristina
- Bravenboer, Bert
- Bumpstead, Suzannah
- Burtt, Noisël P
- Charpentier, Guillaume
- Chines, Peter S
- Cornelis, Marilyn
- Couper, David J
- Crawford, Gabe
- Doney, Alex S F
- Elliott, Katherine S
- Elliott, Amanda L
- Erdos, Michael R
- Fox, Caroline S
- Franklin, Christopher S
- Ganser, Martha
- Gieger, Christian
- Grarup, Niels
- Green, Todd
- Griffin, Simon
- Groves, Christopher J
- Guiducci, Candace
- Hadjadj, Samy
- Hassanali, Neelam
- Herder, Christian
- Isomaa, Bo
- Jackson, Anne U
- Johnson, Paul R V
- Jørgensen, Torben
- Kao, Wen H L
- Klopp, Norman
- Kong, Augustine
- Kraft, Peter
- Kuusisto, Johanna
- Lauritzen, Torsten
- Li, Man
- Lieverse, Aloysius
- Lindgren, Cecilia M
- Lyssenko, Valeriya
- Marre, Michel
- Meitinger, Thomas
- Midthjell, Kristian
- Morken, Mario A
- Narisu, Narisu
- Nilsson, Peter
- Owen, Katharine R
- Payne, Felicity
- Perry, John R B
- Petersen, Ann-Kristin
- Platou, Carl
- Proença, Christine
- Prokopenko, Inga
- Rathmann, Wolfgang
- Rayner, N William
- Robertson, Neil R
- Rocheleau, Ghislain
- Roden, Michael
- Sampson, Michael J
- Saxena, Richa
- Shields, Beverley M
- Shrader, Peter
- Sigurdsson, Gunnar
- Sparsø, Thomas
- Strassburger, Klaus
- Stringham, Heather M
- Sun, Qi
- Swift, Amy J
- Thorand, Barbara
- Tichet, Jean
- Tuomi, Tiinamaija
- van Dam, Rob M
- van Haeften, Timon W
- van Herpt, Thijs
- van Vliet-Ostaptchouk, Jana V
- Walters, G Bragi
- Weedon, Michael N
- Wijmenga, Cisca
- Witteman, Jacqueline
- Bergman, Richard N
- Cauchi, Stephane
- Collins, Francis S
- Gloyn, Anna L
- Gyllensten, Ulf
- Hansen, Torben
- Hide, Winston A
- Hitman, Graham A
- Hofman, Albert
- Hunter, David J
- Hveem, Kristian
- Laakso, Markku
- Mohlke, Karen L
- Morris, Andrew D
- Palmer, Colin N A
- Pramstaller, Peter P
- Rudan, Igor
- Sijbrands, Eric
- Stein, Lincoln D
- Tuomilehto, Jaakko
- Uitterlinden, Andre
- Walker, Mark
- Wareham, Nicholas J
- Watanabe, Richard M
- Abecasis, Gonçalo R
- Boehm, Bernhard O
- Campbell, Harry
- Daly, Mark J
- Hattersley, Andrew T
- Hu, Frank B
- Meigs, James B
- Pankow, James S
- Pedersen, Oluf
- Wichmann, H-Erich
- Barroso, Inês
- Florez, Jose C
- Frayling, Timothy M
- Groop, Leif
- Sladek, Rob
- Thorsteinsdottir, Unnur
- Wilson, James F
- Illig, Thomas
- Froguel, Philippe
- van Duijn, Cornelia M
- Stefansson, Kari
- Altshuler, David
- Boehnke, Michael
- McCarthy, Mark I