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- PMID: 22429116
- UKPMCID: 22429116
- DOI: 10.3109/09513590.2011.633649
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PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.
Mohiyiddeen, Lamiya; Salim, Serena; Mulugeta, Betselot; McBurney, Helen; Newman, William G; Pemberton, Phil; Nardo, Luciano G
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2012;28(5):375-7.
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Full-text held externally
- PMID: 22429116
- UKPMCID: 22429116
- DOI: 10.3109/09513590.2011.633649
Abstract
OBJECTIVES: To determine if an association exists between the follicle-stimulating hormone receptor (FSHR) gene p.Asn680Ser polymorphism and polycystic ovary syndrome (PCOS) or with high anti-mullerian hormone (AMH) levels without PCOS. PATIENTS: Fifty-eight women with PCOS, 24 women with high AMH (>44.5 pmol/L) without PCOS and 80 healthy ethnically matched female controls. MAIN OUTCOME MEASURES: Prevalence of the FSHR p.Asn680Ser polymorphism, baseline serum AMH levels and response to ovulation induction with clomiphene citrate. RESULTS: The frequency of FSHR p.Asn680Ser genotypes were not significantly different between PCOS patients, patients with high AMH without PCOS and controls (p = 0.88). Of the women with PCOS, 34/58 were on clomiphene citrate treatment and 12/34 were resistant. There was no association between sensitivity or resistance to clomiphene and p.Asn680Ser genotypes (p = 0.38). CONCLUSIONS: There is no evidence that FSHR p.Asn680Ser genotypes are associated with PCOS, high AMH levels or response to clomiphene citrate.