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- PMID: 23106574
- UKPMCID: 23106574
- DOI: 10.1111/bjd.12106
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An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.
Ali, F R; Barton, A; Smith, R L I; Bowes, J; Flynn, E; Mangino, M; Bataille, V; Foerster, J P; Worthington, J; Griffiths, C E M; Warren, R B
The British journal of dermatology. 2012;.
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Full-text held externally
- PMID: 23106574
- UKPMCID: 23106574
- DOI: 10.1111/bjd.12106
Abstract
Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. We therefore investigated 18 single nucleotide polymorphisms, previously confirmed as being associated with rheumatoid arthritis (RA), in a UK cohort of 623 patients with early-onset psoriasis (presenting before age 40y) comparing with 2662 control subjects. Our findings confirm the association of early-onset psoriasis with REL (rs13031237, p=0.0027). The minor allele of REL had opposing effects upon susceptibility to disease in psoriasis and RA patients. Similar exploration of additional autoimmune loci and fine-mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.