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- DOI: 10.1093/ageing/afs162
- PMID: 23111338
- UKPMCID: 23111338
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The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men.
Tajar, Abdelouahid; Lee, David M; Pye, Stephen R; O'Connell, Matthew D L; Ravindrarajah, Rathi; Gielen, Evelien; Boonen, Steven; Vanderschueren, Dirk; Pendleton, Neil; Finn, Joseph D; Bartfai, György; Casanueva, Felipe F; Forti, Gianni; Giwercman, Aleksander; Han, Thang S; Huhtaniemi, Ilpo T; Kula, Krzysztof; Lean, Michael E J; Punab, Margus; Wu, Frederick C W; O'Neill, Terence W
Age and ageing. 2013;42(3):352-359.
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Full-text held externally
- DOI: 10.1093/ageing/afs162
- PMID: 23111338
- UKPMCID: 23111338
Abstract
BACKGROUND: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH)D) and PTH.Setting: cross-sectional analysis within the European Male Ageing Study (EMAS).Participants: a total of 1,504 community-dwelling men aged 60-79 years. METHODS: frailty was classified using a frailty phenotype (FP) and frailty index (FI). The association of frailty with 25(OH)D and PTH was examined using multinomial logistic regression; individual FP criteria with 25(OH)D and PTH using binary logistic regression. Results were expressed as relative odds ratios (ROR) and 95% confidence intervals (CIs) for multinomial; odds ratios (OR) and 95% CIs for binary models. RESULTS: using the FP, 5.0% of subjects were classified as frail and 36.6% as prefrail. Lower levels of 25(OH)D were associated with being prefrail (per 1 SD decrease: ROR = 1.45; 95% CI: 1.26-1.67) and frail (ROR = 1.89; 95% CI: 1.30-2.76), after adjusting for age, centre and health and lifestyle confounders (robust group = base category). Higher levels of PTH were associated with being frail after adjustment for confounders (per 1 SD increase: ROR = 1.24; 95% CI: 1.01-1.52). Comparable results were found using the FI. Among the five FP criteria only sarcopenia was not associated with 25(OH)D levels, while only weakness was associated with PTH. CONCLUSION: lower 25(OH)D and higher PTH levels were positively associated with frailty in older men. Prospective data would enable the temporal nature of this relationship to be explored further.
Bibliographic metadata
- Tajar, Abdelouahid
- Lee, David M
- Pye, Stephen R
- O'Connell, Matthew D L
- Ravindrarajah, Rathi
- Gielen, Evelien
- Boonen, Steven
- Vanderschueren, Dirk
- Pendleton, Neil
- Finn, Joseph D
- Bartfai, György
- Casanueva, Felipe F
- Forti, Gianni
- Giwercman, Aleksander
- Han, Thang S
- Huhtaniemi, Ilpo T
- Kula, Krzysztof
- Lean, Michael E J
- Punab, Margus
- Wu, Frederick C W
- O'Neill, Terence W