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IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals

Nolan, K F; Strong, V; Soler, D; Fairchild, P J; Cobbold, S P; Croxton, R; Gonzalo, J A; Rubio, A; Wells, M; Waldmann, H

J Immunol. 2004;172(4):2201-9.

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Abstract

Dendritic cells (DCs) are the professional APCs of the immune system, enabling T cells to perceive and respond appropriately to potentially dangerous microbes, while also being able to maintain T cell tolerance toward self. In part, such tolerance can be determined by IL-10 released from certain types of regulatory T cells. IL-10 has previously been shown to render DCs unable to activate T cells and it has been assumed that this process represents a general block in maturation. Using serial analysis of gene expression, we show that IL-10 pretreatment of murine bone marrow-derived DCs alone causes significant changes in gene expression. Furthermore, these cells retain the ability to respond to Toll-like receptor agonists, but in a manner skewed toward the selective induction of mediators known to enhance local inflammation and innate immunity, among which we highlight a novel CXCR2 ligand, DC inflammatory protein-1. These data suggest that, while the presence of a protolerogenic and purportedly anti-inflammatory agent such as IL-10 precludes DCs from acquiring their potential as initiators of adaptive immunity, their ability to act as initiators of innate immunity in response to Toll-like receptor signaling is enhanced.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Language:
eng
Journal title:
Volume:
172
Issue:
4
Start page:
2201
End page:
9
Total:
-2191
Pagination:
2201-9
ISI Accession Number:
14764687
Related website(s):
  • Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14764687
General notes:
  • Comparative Study Journal Article Research Support, Non-U.S. Gov't United States 1950)
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:184870
Created by:
Nolan, Kathleen
Created:
10th January, 2013, 17:08:57
Last modified by:
Nolan, Kathleen
Last modified:
11th September, 2015, 13:06:45

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