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An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

Ali, F R; Barton, A; Smith, R L I; Bowes, J; Flynn, E; Mangino, M; Bataille, V; Foerster, J P; Worthington, J; Griffiths, C E M; Warren, R B

The British journal of dermatology. 2013;168(4):864-866.

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Abstract

Background  Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. Objectives  By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. Methods  We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. Results  Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. Conclusion  Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Volume:
168
Issue:
4
Pagination:
864-866
Digital Object Identifier:
10.1111/bjd.12106
Pubmed Identifier:
23106574
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:192803
Created by:
Warren, Richard
Created:
22nd April, 2013, 16:10:10
Last modified by:
Warren, Richard
Last modified:
22nd April, 2013, 16:10:10

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