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An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

Ali, F R; Barton, A; Smith, R L I; Bowes, J; Flynn, E; Mangino, M; Bataille, V; Foerster, J P; Worthington, J; Griffiths, C E M; Warren, R B

The British journal of dermatology. 2013;168(4):864-6.

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Abstract

BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
168
Issue:
4
Pagination:
864-6
Digital Object Identifier:
10.1111/bjd.12106
Pubmed Identifier:
23106574
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:198825
Created by:
Griffiths, Christopher
Created:
24th June, 2013, 11:29:18
Last modified by:
Griffiths, Christopher
Last modified:
1st March, 2014, 13:22:02

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