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- PMID: 23106574
- UKPMCID: 23106574
- DOI: 10.1111/bjd.12106
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An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.
Ali, F R; Barton, A; Smith, R L I; Bowes, J; Flynn, E; Mangino, M; Bataille, V; Foerster, J P; Worthington, J; Griffiths, C E M; Warren, R B
The British journal of dermatology. 2013;168(4):864-6.
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Full-text held externally
- PMID: 23106574
- UKPMCID: 23106574
- DOI: 10.1111/bjd.12106
Abstract
BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.