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Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.

Micklefield, Jason

Current Medicinal Chemistry. 2001;8:1157-1179.

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Abstract

A review with 180 refs. Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar-phosphodiester backbone with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and antigen agents, as well as aptamers. Furthermore, backbone modified oligonucleotides have also been used in the development of several alternative strategies, which rely on altogether different mechanisms of action and show significant promise for therapeutic intervention. In this review the latest advances in the synthesis and evaluation of the most promising backbone modified oligodeoxyribonucleotides will be discussed, with a view to their future as novel pharmaceuticals.

Keyword(s)

Double stranded RNA Role: BSU (Biological study, unclassified), MSC (Miscellaneous), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (backbone modification of nucleic acids and synthesis, structure, and therapeutic applications) DNA Role: BSU (Biological study, unclassified), MSC (Miscellaneous), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation) (double-stranded backbone modification of nucleic acids and synthesis, structure, and therapeutic applications)

Bibliographic metadata

Type of resource:
Content type:
Author list:
Published date:
ISSN:
Volume:
8
Start page:
1157
End page:
1179
Pagination:
1157-1179
Digital Object Identifier:
10.2174/0929867013372391
Related website(s):
  • Related website
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1a3478
Created:
6th August, 2009, 10:09:12
Last modified:
14th November, 2012, 01:15:37

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