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- DOI: 10.1039/b718766c
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Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues
B. Amir-Heidari, J. thirlway and J. micklefield
Organic & Biomolecular Chemistry. 2008;6:975-978.
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Full-text held externally
- DOI: 10.1039/b718766c
Abstract
Feeding 5-hydroxy and 5-fluorotryptophan to a Streptomyces coelicolor Trp-auxotrophic strain WH101 results in the production of a number of new calcium-dependent antibiotics (CDAs) possessing modified Trp residues. It is anticipated that this method could be used to modulate the biological properties of Trp-containing nonribosomal peptide natural products, or to generate analogues with useful fluorescent properties for studying biological mechanisms of action.