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- DOI: 10.1039/b616808f
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Cellular targets of natural products.
N. Dixon, L. S. Wong, T. Geerlings and J. Micklefield
Natural Products Reports. 2007;24:1288-1310.
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Full-text held externally
- DOI: 10.1039/b616808f
Abstract
Jason Micklefield graduated from the University of Cambridge in 1993 with a PhD in Organic Chemistry, working with Prof. Sir Alan R. Battersby to complete the first total synthesis of haem d1. He then moved to the University of Washington, USA, as NATO postdoctoral fellow with Prof. Heinz G. Floss investigating various biosynthetic pathways and enzyme mechanisms. In 1995 he began his independent research career at Birkbeck College, University of London, before moving to Manchester in 1998, where he is now Reader in Chemical Biology. His research interests are at the chemistry–biology interface and include the redesign of nucleic acid, small molecule control of gene expression, nonribosomal peptide biosynthesis, biocatalysis and enzyme mechanism. Neil Dixon received his MChem in 2000 and PhD in 2005 from the University of Leeds, where he investigated interactions between synthetic natural product mimics and the osteoporosis target enzyme V-ATPase, with Terry Kee. He is currently a postdoctoral research associate with Jason Micklefield at the Manchester Interdisciplinary Biocentre, where he is investigating small molecule mediated gene regulation. Lu Shin Wong received a PhD in Chemistry in 2005 from the University of Southampton working with Mark Bradley on solid phase combinatorial synthesis. Subsequently he joined the Manchester Interdisciplinary Biocentre as a postdoctoral research associate with Jason Micklefield. His current research interests are focused on the application of chemical biology to surface chemistry and biomolecular-array technologies. Torsten Hans Geerlings completed his PhD in biochemistry in 2003 at the Vrije Universiteit Amsterdam researching the maturation and processing of ribosomal RNA in the yeast Saccharomyces cerevisiae. He then moved to Rijksuniveristeit Groningen as a postdoctoral researcher focused on enhancing protein secretion in the yeast Hansenula polymorpha. Currently he is working as a postdoctoral research associate in the Manchester Interdisciplinary Biocentre with Jason Micklefield and John McCarthy studying the interaction between small natural and synthetic ligands and RNA aptamers.