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Sensitivity and exposure to indoor allergens in adults with differing asthma severity.
Tunnicliffe W, Fletcher T, Hammond K, Roberts K, Custovic A, Simpson A, Woodcock A, Ayres J
Eur Respir J. 1999;13( 3):654-9.
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Abstract
In asthma, it is uncertain whether there is an association between degrees of exposure to domestic allergens and asthma severity.The pattern of sensitivity and exposure to common indoor allergens wasexamined in subjects with differing asthma severity. Sensitivity to housedust mite, dog and cat allergen and exposure to Der p 1, Can f 1 and Fel d1 were assessed by skin prick tests and settled dust analysis in 28subjects with severe asthma and 28 age- and sex-matched subjects with mildasthma (two declined skin prick test). All severe asthmatic subjects hadat least one positive skin test and 20 of the 28 subjects were positive toall three allergens. Fourteen of the 26 subjects with mild asthma who tookskin prick tests were positive to at least one, and one of these subjectswas positive to the three allergens tested. Except for bedroom Fel d 1,the proportion of severe asthmatics both sensitized and exposed to eachallergen at each site was significantly greater than the proportionsensitized and exposed in the mild asthma group. The geometric meanallergen concentrations, with the exception of bedroom Fel d 1, weregreater in sensitized severe asthmatics than the sensitized mildasthmatics, which was significant for Der p 1 in bedroom samples and Can f1 in bedroom and living room samples. These results support an associationbetween the degrees of domestic allergen exposure in sensitizedindividuals and asthma severity.
Keyword(s)
Adult; Animals; Cats; Chi-Square Distribution; Comparative Study; Confidence Intervals; Dogs; Female; Humans; Male; Mites; Patch Tests; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Spirometry; adverse effects: Air Pollution, Indoor; adverse effects: Allergens; analysis: Dust; diagnosis: Asthma; diagnosis: Bronchial Hyperreactivity