Related resources
Search for item elsewhere
University researcher(s)
Academic department(s)
Allergy and infection: understanding their relationship.
Custovic A, Murray CS, Simpson A
Allergy. 2005;60 Suppl 79.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.
Abstract
Sensitization to indoor allergens has long been recognized as a risk factor for asthma and its associated phenotypes.Immunoglobulin E antibody quantification may be used to confirm that aparticular sensitization has a role in the development of respiratorysymptoms. However, in order to use quantitative information effectively,it is essential to understand the factors that contribute to thedeterioration of symptoms and cause exacerbations. One such risk factor ishigh allergen exposure. Worsening asthma control is also associated withvirus infections, in particular rhinovirus infection. Each of thesefactors in isolation is unlikely to have a major effect on symptoms.However, the combination of respiratory virus infection, allergensensitization and concurrent high exposure to allergens markedly increasesthe risk for hospitalization. Further investigation of this synergismcould help to understand the mechanisms of asthma exacerbations and leadto the development of strategies for prevention.