In April 2016 Manchester eScholar was replaced by the University of Manchester’s new Research Information Management System, Pure. In the autumn the University’s research outputs will be available to search and browse via a new Research Portal. Until then the University’s full publication record can be accessed via a temporary portal and the old eScholar content is available to search and browse via this archive.

Brain metabolic differences between sporadic and familial Alzheimer's disease.

Mosconi L, Sorbi S, Nacmias B, De Cristofaro M RT R, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz, KG, Pupi A

Neurology. 2003;61(8).

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.

Abstract

Department of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy.This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p < 0.001). Genetic factors lead to phenotypic differences in AD.PMID: 14581683 [PubMed - indexed for MEDLINE]

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
Volume:
61(8)
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d10991
Created:
29th August, 2009, 15:48:48
Last modified:
27th September, 2010, 10:23:44

Can we help?

The library chat service will be available from 11am-3pm Monday to Friday (excluding Bank Holidays). You can also email your enquiry to us.