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Monitoring of the Effect of Chemotherapy in a Mixed Glioma by C-11-methionine PET
Herholz KG, Kracht L, Heiss W D
Journal of Neuroimaging. 2003;13(3).
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Abstract
Neurologische Universitatsklinik, Max-Planck-Institut fur Neurologische Forschung, Gleueler Str 50, 50931 Koln, Germany. karl.herholz@pet.mpin-koeln.mpg.deThe effect of chemotherapy with procarbazine, CCNU, and vincristine in an anaplastic oligoastrocytoma was monitored by repeated positron emission tomography (PET) with C-11-methionine (C-11-MET). Chemotherapy caused a continuous decline of active tumor volume at a rate of approximately 2.4% per day, resulting in complete remission that persisted until the end of follow-up at 3 years. Thus, the authors conclude that C-11-MET PET may be useful for monitoring chemotherapy in gliomas and deserves further study.PMID: 12889176 [PubMed - indexed for MEDLINE]