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- DOI: 10.1002/mrm.21357
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Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times
O'Connor, JP B, Jackson, A-, Giovanni Buonccoris, Watson, Y, Cheung, SW, Roberts, C, McGrath, DM, Rose, CJ, Dark, PM, Jayson, G-, Buckley, DL, Parker, GJM
Magnetic Resonance in Medicine. 2007;58.
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Full-text held externally
- DOI: 10.1002/mrm.21357
Abstract
Molecular oxygen has been previously shown to shorten longitudinalrelaxation time (T1) in the spleen and renal cortex, butnot in the liver or fat. In this study, the magnitude and temporalevolution of this effect were investigated. Medical air, oxygen,and carbogen (95% oxygen/5% CO2) were administered sequentiallyin 16 healthy volunteers. T1 maps were acquired usingspoiled gradient echo sequences (TR 3.5 ms, TE 0.9 ms, 2°/8°/17°) with six acquisitions on air, 12 on oxygen, 12 oncarbogen, and six to 12 back on air. Mean T1 values and changein relaxation rate were compared between each phase of gasinhalation in the liver, spleen, skeletal muscle, renal cortex, andfat by one-way analysis of variance. Oxygen-induced T1-shorteningoccurred in the liver in fasted subjects (P < 0.001) but notin non-fasted subjects (P 0.244). T1-shortening in spleen andrenal cortex (both P < 0.001) were greater than previouslyreported. Carbogen induced conflicting responses in differentorgans, suggesting a complex relationship with organ vasculature.Shortening of tissue T1 by oxygen is more pronounced andmore complex than previously recognized. The effect may beuseful as a biomarker of arterial flow and oxygen delivery tovascular beds.