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Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia.

Peters, F, Perani, D, Herholz, KG, Holthoff, V, Beuthien-Baumann, B, Sorbi, S, Pupi, A, Degueldre, C, Lemaire, C, Collette, F, Salmon, E

Dement Geriatr Cogn Disord. 2006;21( 5-6):373-9.

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Abstract

Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex (6, 28, -24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects (4, 22, -22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD. Copyright (c) 2006 S. Karger AG, Basel.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
ISSN:
Place of publication:
Switzerland
Volume:
21( 5-6)
Start page:
373
End page:
9
Pagination:
373-9
Digital Object Identifier:
10.1159/000091898
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d14196
Created:
30th August, 2009, 13:05:52
Last modified:
18th November, 2012, 01:05:12

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