In April 2016 Manchester eScholar was replaced by the University of Manchester’s new Research Information Management System, Pure. In the autumn the University’s research outputs will be available to search and browse via a new Research Portal. Until then the University’s full publication record can be accessed via a temporary portal and the old eScholar content is available to search and browse via this archive.

Investigation of genetic variation across PTPN22 in UK rheumatoid arthritis (RA) patients.

Hinks AM, Eyre SS, Barton A, Thomson W, Worthington J

Ann Rheum Dis. 2007;66(5):683-6.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.

Abstract

OBJECTIVE: The aim of this study was to investigate SNPs across the PTPN22 gene region in a UK cohort of RA patients to look for evidence of disease associations independent of the well-characterised R620W variant (rs2476601). METHODS: 951 UK RA cases satisfying ARA criteria and 448 population controls were genotyped for 11 SNPs across the PTPN22 gene region using Sequenom MassArray MassEXTEND technology. Allele, genotype and estimated haplotype frequencies of cases and controls were compared. RESULTS: In addition to the R620W (rs2476601) SNP, three SNPs were associated with RA in this study. The sole haplotype on which the associated T allele of R620W occurred was associated with RA, no other haplotypes showed a significant difference in frequencies between RA cases and controls. CONCLUSION: In contrast to a study of US RA patients we found no evidence of association to PTPN22 independent of the well-characterised R620W variant, suggesting that in UK RA patients this variant alone explains the association with the PTPN22 gene.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
ISSN:
Volume:
66(5)
Start page:
683
End page:
6
Pagination:
683-6
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d14393
Created:
30th August, 2009, 13:10:22
Last modified:
18th December, 2013, 19:35:33

Can we help?

The library chat service will be available from 11am-3pm Monday to Friday (excluding Bank Holidays). You can also email your enquiry to us.