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The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.
Nelson MT, Bonev A
Journal of Clinical Investigation. 2004;113( 7):955-7.
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Abstract
Previous animal studies have demonstrated that the loss of the beta(1) subunit of the large-conductance Ca(2+)-activated K(+) (BK) channel leads to hypertension. A new study demonstrates that a gain in beta(1) subunit function is associated with protection against diastolic hypertension in humans, underscoring the importance of the beta(1) subunit and the BK channel in the regulation of vascular resistance.
Keyword(s)
Humans; Large-Conductance Calcium-Activated Potassium Channels; genetics: Hypertension; genetics: Potassium Channels, Calcium-Activated; genetics: Protein Subunits; genetics: Vascular Resistance