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NFAT regulation in smooth muscle.

Hill-Eubanks D, Gomez M, Stevenson A, Nelson MT

Trends in Cardiovascular Medicine. 2003;13( 2):56-62.

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Abstract

First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth muscle and endothelial cells, and the influence of intravascular pressure on calcium and other signaling pathways creates a calcium-regulatory environment that is arguably unique. This review focuses on mechanisms that control the initial Ca2+/calcineurin-dependent events in NFAT activation, with a particular emphasis on NFAT regulation in native vascular smooth muscle. Also addressed is the role of additional mechanisms that act to modulate calcineurin-dependent NFAT nuclear import/export, mechanisms that may have particular relevance in this tissue.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
ISSN:
Place of publication:
United States
Volume:
13( 2)
Start page:
56
End page:
62
Pagination:
56-62
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d16376
Created:
30th August, 2009, 13:56:06
Last modified:
3rd March, 2010, 17:05:17

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