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Asymptomatic spontaneous cerebral emboli and mood in a cohort of older people: a prospective study.
Oude Voshaar RR, Purandare N, Hardicre J, McCollum CN, Burns AS
Am J Geriatr Psychiatry. 2007;15( 12).
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Abstract
OBJECTIVE: To examine whether asymptomatic spontaneous cerebral emboli (SCE) predicts subsequent depression in older people. METHODS: Prospective cohort study with 2.5 years of follow-up including 96 nondepressed older subjects in primary care. Presence of SCE was measured at baseline by transcranial Doppler of the middle cerebral artery and modeled on depression at follow-up using multiple logistic and linear regression analyses. RESULTS: The prevalence of depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria did not differ significantly between SCE-positive and SCE-negative subjects (27% versus 12%), while the severity of depressive symptoms did (Geriatric Depression Scale: beta = 0.22; Montgomery-Asberg Depression Rating Scale: beta = 0.25). These differences disappeared after adjustment for cardiovascular risk factors. CONCLUSION: These preliminary findings suggest that asymptomatic SCE may be an interceding factor in the development of late-life depression, consistent with the vascular depression hypothesis.
Keyword(s)
Age Factors; Aged; Cohort Studies; Comorbidity; Diagnostic and Statistical Manual of Mental Disorders; Female; Follow-Up Studies; Geriatric Assessment; Humans; Longitudinal Studies; Male; Prospective Studies; Psychiatric Status Rating Scales; Risk Factors; Severity of Illness Index; diagnosis: Depressive Disorder, Major; diagnosis: Intracranial Embolism