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Neurological presentation of Griscelli syndrome: obstructive hydrocephalus without haematological abnormalities or organomegaly.
Rajadhyax M, Neti G, Crow YJ, Tyagi A
Brain Dev. 2007;29( 4):247-50.
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Abstract
Griscelli syndrome is a rare autosomal-recessive disorder characterised by partial albinism, immunodeficiency, organomegaly and accelerated phases. During accelerated phases, pancytopenia, haemophagocytosis, hypoproteinemeia occur which may be accompanied by neurological deterioration. Primary neurological presentation is rare and we report a case that presented with obstructive hydrocephalus and infiltrative lesions in the brain unaccompanied by other features of accelerated phase. Biopsy of these lesions demonstrated sinus histiocytosis. Electron microscopy of hair shaft and genetic studies established the diagnosis of Griscelli disease with RAB 27A mutation.
Keyword(s)
Child, Preschool; Female; Humans; Mutation; Syndrome; genetics: Hydrocephalus; genetics: Immunologic Deficiency Syndromes; genetics: Piebaldism; genetics: rab GTP-Binding Proteins; methods: Magnetic Resonance Imaging