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Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: Standardized quantities and symbols
Tofts, P.S., Brix, G., Buckley, DL, Evelhoch, J.L., Henderson, E., Knopp, M.V., Larsson, H.B., Lee, T.Y., Mayr, N.A., Parker, GJM, Port, R.E., Taylor, J., Weisskoff, R.M
Journal of Magnetic Resonance Imaging. 1999;10, 3:223-232.
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Abstract
We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast-enhanced T(1)- weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd-DTPA). These include a) the volume transfer constant K(trans) (min(-1)); b) the volume of extravascular extracellular space (EES) per unit volume of tissue v(e) (0 < v(e) < 1); and c) the flux rate constant between EES and plasma k(ep) (min(- 1)). The rate constant is the ratio of the transfer constant to the EES (k(ep) = K(trans)/v(e)). Under flow-limited conditions K(trans) equals the blood plasma flow per unit volume of tissue; under permeability- limited conditions K(trans) equals the permeability surface area product per unit volume of tissue. We relate these quantities to previously published work from our groups; our future publications will refer to these standardized terms, and we propose that these be adopted as international standards. J. Magn. Reson. Imaging 10:223-232, 1999. Copyright 1999 Wiley-Liss, Inc