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Serum esterase activities and hyperlipidaemia in the streptozotocin-diabetic rat.
Patel B, Mackness M, Harty D, Arrol S, Boot-Handford RR, Durrington PN
Biochim Biophys Acta. 1990;1035( 1):113-6.
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Abstract
The levels of activity of four serum esterases were measured in control and streptozotocin-diabetic rats for a period of 6 months. Pseudocholinesterase activity was significantly elevated in the diabetic rats at all time points tested, reaching 250% of the control activity at 6 months. Levels of paraoxonase activity progressively decreased with time in the diabetic rats, being 36% lower than in controls at 6 months. No significant differences in either serum arylesterase or carboxylesterase activity between control and diabetic rats were observed.
Keyword(s)
Animals; Male; Rats; Streptozocin; blood: Diabetes Mellitus, Experimental; blood: Esterases; etiology: Hyperlipidemias; metabolism: Blood Glucose; metabolism: Cholesterol; metabolism: Triglycerides