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Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population.

Newman WG, Zhang Q, Liu X, Amos C, Siminovitch K

J Clin Gastroenterol. 2009;43( 5).

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Abstract

GOALS: To establish the relevance of variants in the IL-23R and ATG16L1 genes in inflammatory bowel disease (IBD). AIM: Three recent genome wide association studies have identified variants in the IL-23R and ATG16L1 genes, which modulate susceptibility to Crohn's disease (CD). METHODS: We genotyped 1028 IBD patients, including 443 CD and 347 ulcerative colitis (UC) non-Jewish cases, 238 (183 CD and 55 UC) Jewish cases, and 1005 ethnically matched control subjects for 18 and 11 variants, respectively, in the IL-23R and ATG16L1 genes, including the IL-23R (R381Q) and ATG16L1 (T216A) variants, previously associated with CD. RESULTS: Single nucleotide polymorphisms within each of 3 haplotype blocks across the IL-23R gene were associated with an increased risk of CD. Notably, the minor allele of the IL-23R R381Q variant was present in 2.9% of cases and 6.0% controls (P=0.0001, odds ratio=0.48, 95% confidence interval 0.33-0.69). Homozygosity for the minor (T) allele of the ATG16L1 T216A polymorphism was strongly protective for CD (P=0.0001, odds ratio=0.51, 95% confidence interval 0.38-0.68). No phenotypic associations were detected and no interactions between the genes to increase disease risk were established. CONCLUSIONS: We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC. Our results also suggest that these variants act independently of one another to influence risk and pathogenesis of IBD.

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Place of publication:
United States
Volume:
43( 5)
Digital Object Identifier:
10.1097/MCG.0b013e318168bdf0
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d20228
Created:
30th August, 2009, 15:37:08
Last modified by:
Newman, William
Last modified:
10th April, 2013, 20:12:40

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