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Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients.
Donn RP, Farhan A, Barrett J, Thomson W, Worthington J, Ollier Bill
Rheumatology (Oxford). 1999;38( 2).
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Abstract
OBJECTIVE: To determine whether interleukin 1 alpha (IL-1alpha) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). PATIENTS AND CONTROLS: A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. METHODS: The IL-1alpha promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1alpha intronic microsatellite repeat. RESULTS: No association was observed between IL-1alpha polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1alpha polymorphisms and chronic anterior uveitis was found. CONCLUSIONS: IL-1alpha is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1alpha in Norwegian JCA patients.
Keyword(s)
Adult; Child; Child, Preschool; Great Britain; Humans; Infant; Mutation; Polymorphism, Genetic; Promoter Regions, Genetic; genetics: Arthritis, Juvenile Rheumatoid; genetics: Interleukin-1