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Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients.

Donn RP, Farhan A, Barrett J, Thomson W, Worthington J, Ollier Bill

Rheumatology (Oxford). 1999;38( 2).

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Abstract

OBJECTIVE: To determine whether interleukin 1 alpha (IL-1alpha) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). PATIENTS AND CONTROLS: A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. METHODS: The IL-1alpha promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1alpha intronic microsatellite repeat. RESULTS: No association was observed between IL-1alpha polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1alpha polymorphisms and chronic anterior uveitis was found. CONCLUSIONS: IL-1alpha is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1alpha in Norwegian JCA patients.

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Place of publication:
ENGLAND
Volume:
38( 2)
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d21646
Created:
30th August, 2009, 16:12:57
Last modified by:
Ingram, Mary
Last modified:
20th September, 2015, 12:14:41

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